abstract：Purpose:To evaluate the influence of systemic and ocular factors on the foveal avascular zone (FAZ) area in young Chinese subjects' healthy eyes. Methods:The current observational, cross-sectional study included 344 eyes from 172 healthy individuals (103 women, 69 men). Optical coherence tomography angiography realize...

journal_title：BioMed research international

authors： Zhou Y,Zhou M,Gao M,Liu H,Sun X

更新日期：2020-03-24 00:00:00

abstract：:Angiopoietin-like protein 4 (ANGPTL4) is widely known as a key regulator of lipid metabolism. We investigated the relationship between ANGPTL4 expression in serum or urine and blood lipid or urine protein levels of patients with hyperlipidemia- (HL-) related proteinuria. Sixty-eight patients with HL-related proteinuri...

journal_title：BioMed research international

authors： Gao X,Zhang M,Feng W,Xu Z,Wang Y,Shi L,Zhang J

更新日期：2020-03-23 00:00:00

abstract：Purpose:It is well known that interstitial photodynamic therapy (iPDT) of large tumors requires effective planning to ensure efficient delivery of therapeutic dose to the target tumors. This should be achieved in parallel with minimal damage to the nearby intact tissues. To that end, clinical iPDT can be attained using...

journal_title：BioMed research international

authors： Ismael FS,Amasha H,Bachir W

更新日期：2020-03-23 00:00:00

abstract：:Colorectal cancer (CRC) is a common malignancy with high morbidity and mortality worldwide. To date, chemotherapy plays an important role in the treatment of CRC patients. Multidrug resistance (MDR) is one of the major hurdles in chemotherapy for CRC, and the underlying mechanisms need to be explored. Studies have dem...

journal_title：BioMed research international

authors： Yuan S,Tao F,Zhang X,Zhang Y,Sun X,Wu D

更新日期：2020-03-18 00:00:00

abstract：Background:Liver ischaemia-reperfusion injury (IRI) remains a problem in liver transplantation. Interleukin-4 (IL-4) has been found to reduce liver IRI, but the exact mechanism remains unclear. Methods:Donor livers were infused with recombinant IL-4 or normal saline during cold storage, and the hepatocellular apoptosi...

journal_title：BioMed research international

authors： Deng M,Wang J,Wu H,Wang M,Cao D,Li J,Wu Y,Gong J

更新日期：2020-03-18 00:00:00

abstract：Background:Oxidative stress is an important factor during age-related cataract formation. Apoptosis and autophagy induced by oxidative stress have been reported as key factors in age-related cataract. In our research, we investigated the role of let-7c-3p in the regulation of autophagy and apoptosis during the formatio...

journal_title：BioMed research international

authors： Li T,Huang Y,Zhou W,Yan Q

更新日期：2020-03-16 00:00:00

abstract：:Estimation of the spread and advancement of Plasmodium falciparum artemisinin-resistant parasites can be done by probing polymorphisms in the kelch (Pfk13) domain (a validated molecular marker). This study aimed to provide baseline information for future artemisinin surveillance by analyzing the k13-propeller domain i...

journal_title：BioMed research international

authors： Rana R,Ranjit M,Bal M,Khuntia HK,Pati S,Krishna S,Das A

更新日期：2020-03-15 00:00:00

abstract：:Several intestinal parasites of baboons are of zoonotic importance, especially where there is considerable interaction between the baboons and humans. The identification of gastrointestinal parasite infections of baboons (Papio anubis) was undertaken at the Shai Hills Reserve Resort, Ghana. A total of 51 faecal sample...

journal_title：BioMed research international

authors： Larbi JA,Akyeampong S,Abubakari A,Offei Addo S,Okoto D,Hanson H

更新日期：2020-03-11 00:00:00

abstract：:In the present study, we explored SA's activity against DOX-induced cardiotoxicity and revealed its underlying mechanisms. Male Wistar rats (weight, 190-210g; n = 6) were randomly divided into four groups: group I, normal control; group II, DOX 15 mg/kg via intraperitoneal (ip) route; group III, administered DOX+SA 20...

journal_title：BioMed research international

authors： Bin Jardan YA,Ansari MA,Raish M,Alkharfy KM,Ahad A,Al-Jenoobi FI,Haq N,Khan MR,Ahmad A

更新日期：2020-03-10 00:00:00

abstract：Background:The purpose of this study was to evaluate the association between the non-high-density lipoprotein cholesterol (non-HDL-C) to high-density lipoprotein cholesterol (HDL-C) ratio and the risk of coronary artery disease (CAD). We also explored the potential role of non-HDL-C/HDL-C in the prognosis of CAD. Meth...

journal_title：BioMed research international

authors： You J,Wang Z,Lu G,Chen Z

更新日期：2020-03-07 00:00:00

abstract：:Cutaneous squamous cell carcinoma (cSCC) is one of the most common skin cancers. In the treatment of cSCC, it is necessary to remove it completely, and reconstructive surgery, such as a skin graft or a local or free flap, will be required, depending on the size, with donor-site morbidity posing a burden to the patient...

journal_title：BioMed research international

authors： Mitsui T,Morimoto N,Mahara A,Notodihardjo SC,Le TM,Munisso MC,Kakudo N,Yamaoka T,Kusumoto K

更新日期：2020-03-07 00:00:00

abstract：:Introduction. In the field of orthopaedic surgery, the use of osteogenic material in larger defects is essential. Autograft and allograft are both known methods, and autograft is believed to be the best choice. But autograft is associated with additional invasive procedures which can prove difficult in fragile patient...

journal_title：BioMed research international

authors： Dreyer CH,Rasmussen M,Pedersen RH,Overgaard S,Ding M

更新日期：2020-03-03 00:00:00

abstract：:Stem cell-based therapy has been considered as a promising option in the treatment of ischemic heart disease. Although stem cell administration resulted in the temporary improvement of myocardial contractility in the majority of studies, the formation of new cardiomyocytes within the injured myocardium has not been co...

journal_title：BioMed research international

authors： Belostotskaya G,Hendrikx M,Galagudza M,Suchkov S

更新日期：2020-03-03 00:00:00

abstract：:Astragalus membranaceus polysaccharide (APS) components are main ingredients of TCM and have proven efficacy to activate T cells and B cells, enhancing immunity in humans. In this study, elevated cytokine and anti-PD-1 antibody titers were found in mice after immunization with APS. Therefore, phage-display technology ...

journal_title：BioMed research international

authors： Chang FL,Tsai KC,Lin TY,Yang TW,Lo YN,Chen WC,Chang JH,Lu MK,Chiou CT,Chen PH,Yen Y,Pan SL,Lee YC

更新日期：2020-03-03 00:00:00

abstract：Objective:To compare the effectiveness of arthroscopic partial meniscectomy (APM) and physical therapy (PT) for degenerative meniscus tears. Method:We conducted a literature search through PubMed, Embase, the Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov. Randomized controlled trials in adults...

journal_title：BioMed research international

authors： Li J,Zhu W,Gao X,Li X

更新日期：2020-03-03 00:00:00

abstract：Purpose:To explore the effects of depression on cardiac autonomic nerve function and related metabolic pathways, the heart rate variability (HRV) and urinary differential metabolites were detected on the college students with depression. Methods:12 female freshmen with depression were filtered by the Beck Depression I...

journal_title：BioMed research international

authors： Zhao S,Chi A,Yan J,Yao C

更新日期：2020-02-27 00:00:00

abstract：Aim:This study aims to evaluate the accuracy of scanned images of 4 clinically used intraoral scanners (CS3600, i500, Trios3, Omnicam) when scanning the surface of full arch models with various kinds of orthodontic brackets in the presence of artificial saliva. Materials and Methods. Four study models were prepared; bo...

journal_title：BioMed research international

authors： Song J,Kim M

更新日期：2020-02-27 00:00:00

abstract：:Introduction. NOTCH pathway and TP53 protein are involved in the development of fibrosis and autoimmune disorders, respectively. The aim of this study was to evaluate the role of single nucleotide polymorphisms (SNPs) of NOTCH3 and TP53 genes and serum anti-TP53 antibodies with the susceptibility, clinical subset of s...

journal_title：BioMed research international

authors： Zmorzyński S,Wojcierowska-Litwin M,Kowal M,Michalska-Jakubus M,Styk W,Filip AA,Walecka I,Krasowska D

更新日期：2020-02-25 00:00:00

abstract：Objective:Study the effect of quality control circle (QCC) in promoting the usage of rubber dams (RD) in root canal treatment of chronic pulpitis in primary teeth. Methods:Set up a quality control group to increase the amount of rubber dams used in the treatment of chronic pulpitis in primary teeth. Monthly monitoring...

journal_title：BioMed research international

authors： Jingxian F,Yang L,Qiong L,Hong Q,Hedi L,Jinglan Z,Fang L,Jing Y,Xiaoming W,Yingying S

更新日期：2020-02-24 00:00:00

abstract：Purpose:Technetium-99m diethylene triamine pentaacetic acid (Tc-99m DTPA) renal dynamic scintigraphy is a widely used imaging technique that evaluates renal function of patients with extrarenal abnormalities, but its clinical value in potentially offering us information on proliferation of liposarcoma has not yet been ...

journal_title：BioMed research international

authors： Wang Y,Li M,Dai S,Li Y

更新日期：2020-02-22 00:00:00

abstract：:A series of sulfonamide-bearing azaheterocyclic Schiff base derivatives 3(a-j) were synthesized as carbonic anhydrase inhibitors. The substituted benzene sulfonyl chlorides 1(a-d) were reacted with N2H4 to get aromatic sulfonyl hydrazides 2(a-d). The intermediate hydrazides 2(a-d) were treated with substituted aldehyd...

journal_title：BioMed research international

authors： Abas M,Rafique H,Shamas S,Roshan S,Ashraf Z,Iqbal Z,Raza H,Hassan M,Afzal K,Rizvanov AA,Asad MHHB

更新日期：2020-02-20 00:00:00

abstract：Objective:To observe the effect of adenosine A1 receptor in the hippocampus of mice on GSK-3β phosphorylation level and elucidate the underlying mechanisms of electroacupuncture pretreatment by activating Α1 receptor mediating cerebral ischemia-reperfusion injury. Method:The model of middle cerebral artery occlusion (...

journal_title：BioMed research international

authors： Geng W,Cai L,Han K,Li D,Mo Y,Dai Q,Tang H,Zhang M,Akuetteh PDP,Balelang MF,Wang J

更新日期：2020-02-20 00:00:00

abstract：:Alzheimer's disease is a multifactorial neurodegenerative disease characterized by progressive cognitive dysfunction. It is the most common form of dementia. The pathologic hallmarks of the disease include extracellular amyloid plaque, intracellular neurofibrillary tangles, and oxidative stress, to mention some of the...

journal_title：BioMed research international

authors： Assefa BT,Tafere GG,Wondafrash DZ,Gidey MT

更新日期：2020-02-18 00:00:00

abstract：:Introduction. The poor long-term adherence is known to affect the efficacy of allergen immunotherapy (AIT). In the case of injection AIT (SCIT), one of the main determinants is the inconvenience for patients to undergo prolonged build-up phases. Thus, simplifying the time schedule of the induction protocol could be ef...

journal_title：BioMed research international

authors： Caruso C,Bramé B,Bagnasco D,Cocconcelli A,Ortolani V,Pravettoni V,Scarpa S,Zisa G,Passalacqua G,Colantuono S

更新日期：2020-02-18 00:00:00

abstract：:The aim of this study was to investigate the anticancer and antioxidant activities as well as the safety of the brown algae Dictyota dichotoma of the Western seacoast of Yemen. Cytotoxicity of methanol extract of D. dichotoma and several of its fractions, petroleum ether, chloroform, ethyl acetate, n-butanol, and aque...

journal_title：BioMed research international

authors： El-Shaibany A,Al-Habori M,Al-Maqtari T,Al-Mahbashi H

更新日期：2020-02-17 00:00:00

abstract：Background:According to several studies, the autoimmune response may lead to osteoarthritis and dyslipidemia and may affect the homeostasis of the human body's internal environment and then cause its own immune regulation. Consequently, the risk of osteoarthritis might be increased by dyslipidemia, but this association...

journal_title：BioMed research international

authors： Xiong J,Long J,Chen X,Li Y,Song H

更新日期：2020-02-15 00:00:00

abstract：:Ovarian cancer (OvCa) is an intractable gynecological malignancy due to the high recurrence rate. Several molecular biomarkers have been previously screened for early identifying patients with a high recurrence risk and poor prognosis. However, all the known studies focused on a single type of RNAs, not integrating va...

journal_title：BioMed research international

authors： Zhang Y,Ye Q,He J,Chen P,Wan J,Li J,Yang Y,Li X

更新日期：2020-02-14 00:00:00

abstract：:Growing evidence suggests that increased arginase activity affects vital bioprocesses in various systems and universally mediates the pathogenesis of numerous metabolic diseases. The adverse effects of arginase are associated with a severe decline in L-arginine bioavailability, which leads to nitric oxide synthase sub...

journal_title：BioMed research international

authors： Gilinsky MA,Polityko YK,Markel AL,Latysheva TV,Samson AO,Polis B,Naumenko SE

更新日期：2020-02-12 00:00:00

abstract：:The cytosolic isozyme of phosphoenolpyruvate carboxykinase (PCK1) was the first rate-limiting enzyme in the gluconeogenesis pathway, which exerted a critical role in maintaining the blood glucose levels. PCK1 has been established to be involved in various physiological and pathological processes, including glucose met...

journal_title：BioMed research international

authors： Yuan Y,Lin JY,Cui HJ,Zhao W,Zheng HL,Jiang ZW,Xiong XD,Xu S,Liu XG

更新日期：2020-02-12 00:00:00

abstract：Purpose:To evaluate the effects of intravitreal ranibizumab (IVR) treatment on the blood flow of the optic nerve head (ONH) and of retinal vessels of the peripapillary region of eyes with diabetic macular edema (DME) assessed using laser speckle flowgraphy (LSFG). Methods:Forty eyes of 30 patients treated with IVR for...

journal_title：BioMed research international

authors： Toto L,Evangelista F,Viggiano P,Erroi E,D'Onofrio G,Libertini D,Porreca A,D'Aloisio R,Mariacristina P,Di Antonio L,Di Nicola M,Mastropasqua R

更新日期：2020-02-10 00:00:00

abstract：Objective:We identified differentially expressed microRNAs (DEMs) between esophageal carcinoma (ESCA) tissues and normal esophageal tissues. We then constructed a novel three-miRNA signature to predict the prognosis of ESCA patients using bioinformatics analysis. Materials and Methods. We combined two microarray profil...

journal_title：BioMed research international

authors： Wu K,Zhang C,Zhang C,Dai D

更新日期：2020-02-10 00:00:00

abstract：Objective:To explore the ability of asiatic acid to interfere with the invasion and proliferation of breast cancer cells by inhibiting WAVE3 expression and activation through the PI3K/AKT signaling pathway. Methods:The MDA-MB-231 cells with strong invasiveness were screened by transwell assay, and plasmids with high e...

journal_title：BioMed research international

authors： Gou XJ,Bai HH,Liu LW,Chen HY,Shi Q,Chang LS,Ding MM,Shi Q,Zhou MX,Chen WL,Zhang LM

更新日期：2020-02-10 00:00:00

abstract：:Saponins are a group of naturally occurring plant glycosides with the features of their strong foam-forming properties and multibiological effects such as antitumor activity. Though Misaponin B, one of the triterpenoid saponins from Madhuca longifolia, is known to have spermicidal and antioxidant activity, the other b...

journal_title：BioMed research international

authors： Won G,Jung JH,Sohn EJ,Park JE,Kim H,Lee HJ,Shim BS,Kim SH

更新日期：2020-02-07 00:00:00

abstract：:In renal cell carcinoma, chromophobe renal cell carcinoma (ChRCC) is a distinct subtype, whose clinical manifestations often lack specificity, and the molecular mechanisms of ChRCC tumorigenesis remain generally vague. The target of this study was to discover novel biomarkers involved in ChRCC by integrated bioinforma...

journal_title：BioMed research international

authors： Zhang W,Xu Y,Zhang J,Wu J

更新日期：2020-02-07 00:00:00

abstract：:Neutrophils comprise the first line of innate immune defense during a host-pathogen interaction. They attack microorganisms directly through three different methods, of which, phagocytosis and degranulation have been known and well-studied for decades. The formation of neutrophil extracellular traps (NETs) is the thir...

journal_title：BioMed research international

authors： Alasmari SZ

更新日期：2020-02-01 00:00:00

abstract：:The simultaneous effect of flexible wall and multiple stenoses on the flow and mass transfer of blood is investigated through numerical computation and simulations. The solution is obtained using the Marker and Cell technique on an axisymmetric model of Newtonian blood flow. The results compare favorably with physical...

journal_title：BioMed research international

authors： Alsemiry RD,Sarifuddin,Mandal PK,Sayed HM,Amin N

更新日期：2020-01-31 00:00:00

abstract：:Germacrone, a natural 10-membered monocyclic sesquiterpene with three double bonds and a ketone, was isolated from the roots of traditional Chinese medicine Saussurea costus (SC). The pharmacological value and intrinsic mechanism of germacrone in the treatment of esophageal squamous cell carcinoma (ESCC) are still unc...

journal_title：BioMed research international

authors： Zhang R,Hao J,Guo K,Liu W,Yao F,Wu Q,Liu C,Wang Q,Yang X

更新日期：2020-01-30 00:00:00

abstract：:Melanoma is a human skin malignant tumor with high invasion and poor prognosis. The limited understanding of genomic alterations in melanomas in China impedes the diagnosis and therapeutic strategy selection. We conducted comprehensive genomic profiling of melanomas from 39 primary and metastatic formalin-fixed paraff...

journal_title：BioMed research international

authors： Luo Y,Zhang Z,Liu J,Li L,Xu X,Yao X,Dai Z,Wang X,Yang S,Wu H,Bu J,Wu Y,Xiang T,Li X

更新日期：2020-01-30 00:00:00

abstract：:Hypoxia plays an essential role in orchestrating Epithelial-mesenchymal transition and promoting metastasis of colorectal cancer. However, the underlying mechanisms are still not well elucidated. Here, we present that hypoxic exposure causes endoplasmic reticulum stress and activates the unfolded protein response path...

journal_title：BioMed research international

authors： Zheng H,Wu Y,Guo T,Liu F,Xu Y,Cai S

更新日期：2020-01-27 00:00:00

abstract：Background:Comparison of single-level open and minimally invasive transforaminal lumbar interbody fusions (O-TLIF and MI-TLIF) of a single surgeon and presentation of his MI-TLIF learning curve in a retrospective observational cohort study. Methods:27 MI-TLIF and 31 O-TLIF patients, performed between 03/01/2013 and 03...

journal_title：BioMed research international

authors： Kovari VZ,Kuti A,Konya K,Szel I,Szekely AK,Szalay K

更新日期：2020-01-25 00:00:00